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Namely, they found that the common GLP1R variant Gly168Ser (rs6923761) was associated with poorer response, while rare variants in ARRB1 (notably Thr370Met) enhanced response by reducing GLP1R internalisation and boosting cAMP and insulin secretion, with stronger effects in Hispanic and American Indian/Alaska Native populations

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Shin SM, Baek EJ, Kim KH, Kim KJ, Park EJ

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These results indicate that the loss of cellular glutathione and increase in oxidative stress alters vitamin D metabolism genes and vitamin D receptors, which can predispose the body to 25(OH)VD 3 deficiency

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