It works by mimicking the action of Glucagon-like Peptide-1 (GLP-1), promoting insulin secretion, inhibiting glucagon secretion, and delaying gastric emptying, which helps control blood sugar levels and aids in weight loss
A historical reason is that DPP-4 inhibitors were introduced in 2006 and therefore, the practical experience with this class of agents is deeper and more widespread than that with SGLT-2 inhibitors
How does oral GLP-1 medication work
A recombinant human glucagon-like peptide (GLP)-1albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis
These drugs, including Liraglutide, Semaglutide, and Dulaglutide, are designed to mimic the action of the natural hormone GLP-1 (glucagon-like peptide-1)
Gallbladder disease risk may be increased with GLP-1 receptor agonists, particularly with substantial weight loss