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Conflict of interest statement Within the last 36 months, FK has served on scientific advisory panels and/or been part of speaker's bureaus for, served as a consultant to and/or received research support from Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Gubra, MedImmune, MSD/Merck, Mundipharma, Norgine, Novo Nordisk, Sanofi and Zealand Pharma

By week 6 to 8, approximately 7080% of patients report significant improvement or complete resolution of treatment-related tiredness

Importance of reward and prefrontal circuitry in hunger and satiety: PraderWilli syndrome vs simple obesity