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Its mechanism integrates two metabolically opposing yet complementary pathways: GLP-1 receptor agonism provides the established incretin effects: glucose-dependent insulin secretion enhancement, suppression of inappropriate glucagon release from alpha cells, delayed gastric emptying, and central appetite suppression through hypothalamic and brainstem satiety circuits

Diabet Med 2012;29:12601267

It causes uncomfortable symptoms that can really affect a persons life

Other signs and symptoms include fatigue, swollen lymph nodes, weight loss, trouble breathing or chronic cough, loss of appetite and bone pain

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Finally, the membranes were washed three times with TBST