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however, after screening only eligible systematic reviews were included, minimizing any impact on the final synthesis

References: Federal Drugs and Cosmetics Act (FD&C Act), 21 USC 9 pharmacology-considerations-peptide-drug-products drug-substances-nominated-use-compounding

*Correspondence: Monika Proszkowiec-Weglarz [email protected] This article was submitted to Animal Nutrition and Metabolism, a section of the journal Frontiers in Veterinary Science Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Sanz-Cuesta T, Escortell-Mayor E, Cura-Gonzalez I et al (2020) Oral versus intramuscular administration of vitamin B12 for vitamin B12 deficiency in primary care: a pragmatic, randomized, non-inferiority clinical trial (OB12)

Modulates the nitric oxide (NO) pathway, improving circulation and protecting endothelial cells

The evidence is largely anecdotal, but the low risk and potential benefit make it worth trying