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The determination of a mechanism of action of apigenin (10, 20 mg/kg) was performed in another study that confirmed reduced inflammation, mucus secretion evident by PAS staining, and airway remodeling evident by collagen volume that was characterized by asthma-related inflammatory cytokine and apoptosis reduction in BALF, including IgE, IL-4, IL-5, IL-13, and IL-17 [139]

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