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During the recruitment appointment and subsequent follow-up appointments at six and twelve months, the clinical status and mental health of all volunteers were evaluated, peripheral blood samples were collected, 45 plasma biomarkers (cytokines, chemokines, and growth factors) were assessed, and a comprehensive investigation was conducted using neuropsychological and ophthalmological tests, PET-CT, and magnetic resonance neuroimaging

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Insulin glargine injection has received marketing authorization from the European Commission (EC), while for insulin lispro injection and insulin aspart injection, it has received the positive opinion from CHMP of EMA

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