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The ability of IL-1 to induce chondrocyte catabolism [121] has been well known for a long time, but it is only recently that IL-1 has been shown to disrupt chondrocyte iron homeostasis [117] and trigger chondrocyte ferroptosis [22, 122]

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However, during an initial loading phase, a more frequent schedule may be necessary

Yes, orforglipron is an oral GLP-1 receptor agonist currently under development, showing promising results in clinical trials for glycemic control and weight loss

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Different experimental approaches in modelling cataractogenesis: an overview of selenite-induced nuclear cataract in rats