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Medical management includes starting PGE1 to keep the ductus arteriosus open and treatment of metabolic acidosis if present

For optimal results, Hist Reset should be paired with a temporary low-histamine diet to reduce the incoming burden on the "histamine bucket." As the mast cells stabilize and the enzymatic clearance pathways (DAO, HNMT, ALDH) become more efficient, many patients find they are eventually able to reintroduce previously triggering foods with much greater tolerance

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10.1016/j.brainres.2017.10.012 Brain Res

10.1080/17425255.2018.1541981 27 ChangH