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These substitutions protect against dipeptidyl peptidase-IV (DPP-IV) cleavage, the enzyme that destroys natural GHRH within minutes (Alba et al., J Med Chem 2006)

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Estudos em modelos animais indicam que esses frmacos aumentam a fosforilao da via ERK1/2, um mecanismo crucial para a proteo neuronal

It is a methodologically robust piece of work: two phase 3 trials, randomized, double-blind, placebo-controlled, with 3,808 participants across 566 centers in 40 countries