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doi: 10.1007/s11103-007-9158-7

Rights and permissions About this article Cite this article Goldney, J., Davies, M.J

Conclusion Melanosis coli is a common adverse effect of chronic laxative use which is more common in elderly population with constipation

[1] Most are administered via subcutaneous injection, with dosing frequencies ranging from twice daily to once weekly, depending on the specific formulation

Risks of extended calorie restriction include nutritional deficiencies, bone loss, hormonal disruption, and an association with disordered eating behaviours