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Adding cagrilintide at a moderate dose (1.0-2.4 mg) provides amylin-mediated appetite suppression through a completely different neuronal circuit, which may allow you to use a lower retatrutide dose (8 mg instead of 12 mg) while achieving comparable or superior total metabolic effect

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In addition, age dependent accretion of dysfunctional mitochondria elevates stress level, which is exhibited by high levels oxidized products such as protein carbonyls and lipid peroxides 42

These results show that to reach a specific steady-state level of blood NAD + , different individuals required different dosages