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The question is whether that caution is traveling far enough upstream, before patients are symptomatic

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Severe, persistent, or worsening abdominal pain

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Melatonin exerts protective effects in an ILC2-biased model of allergic airways disease, even in the presence of canonical receptor blockade To determine whether the protective effects of melatonin extended beyond allergen-driven disease, we next employed an ILC2-biased IL-33 model of allergic airways inflammation ( Figure 2A )

4.2 Future directions and strategic innovations To overcome these challenges, interdisciplinary collaboration integrating medicinal chemistry, pharmacology, and chemical biology is imperative