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doi: 10.1016/j.freeradbiomed.2011.12.020

If that's the reason

In contrast to Ozempic, berberine does not slow down GI motility

Cheng Y, Zhang X, Sun T, Tian Q, Zhang WH (2018) Glutamate receptor homolog 3.4 is involved in regulation of seed germination under salt stress in Arabidopsis

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ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway