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A systematic review involving 6,370 participants found that on average, people lose around 16 kg while on treatment but regain about 60% of that weight within a year of stopping
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These two mechanisms operate through distinct receptor systems and intracellular signaling cascades, and preclinical evidence suggests that concurrent activation may produce a greater growth hormone response than either compound alone
[DOI] [PMC free article] [PubMed] [Google Scholar] 273
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