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The non-coenzyme action of thiamine in neurotransmission is further supported by the action of the thiamine analog oxythiamine, whose diphosphorylated derivative (oxyThDP), formed by TPK in vivo , is an antagonist of the coenzyme action of thiamine

Solitano V, Bernstein CN, Dotan I, Dignass A, Domilici R, Dubinsky MC, Gearry RB, Hart A, Kaplan GG, Ma C, Magro F, Mak JWY, Ng SC, Panaccione R, Raja S, Rubin DT, Siegel CA, Jairath V, Peyrin-Biroulet L, Danese S (2025) Shaping the future of inflammatory bowel disease: a global research agenda for better management and public health response

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