Chen J, Lai J, Yang L, Ruan G, Chaugai S, Ning Q, et al
Oral administration of the probiotic strain escherichia coli nissle 1917 reduces susceptibility to neuroinflammation and repairs experimental autoimmune encephalomyelitis-induced intestinal barrier dysfunction

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It does this primarily by promoting angiogenesis, the formation of new blood vessels, which is critical for tissue repair
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These baseline differences may have influenced both the selection of oral semaglutide dosage and subsequent treatment outcomes