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Cardiovascular Risk Reduction: With the 2023 approval for reducing major adverse cardiovascular events, GLP-1 receptor agonists are now used within comprehensive cardiovascular risk-management strategies for patients with type 2 diabetes and established cardiovascular disease

While more studies are needed, current evidence supports their potential to reduce CV risk through multiple direct and indirect mechanisms, offering hope for improved outcomes in a population with historically elevated premature mortality

doi:10.1016/j.jhsa.2009.04.031

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Allow the initial dose to establish baseline response before making adjustments

Heneka et al., 2025) without any contribution from bone-marrow-derived monocytes to the microglial pool, at least under homeostatic conditions (Masuda et al., 2020), and healthy brain parenchyma has little macrophage and monocyte infiltration due to blood-brain barrier (BBB)