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Experienced users and clinic protocols recommend taking breaks

doi:10.1016/j.drugalcdep.2005.09.002

The effect on truly "stubborn" subcutaneous fat (which is resistant due to higher alpha-2 adrenergic receptor density) is unclear

Recent discoveries on the actions of the human tripeptide GHK (glycyl-L-histidyl-L-lysine) to reset gene expression of human cells to a more healthy state may open a door to the therapeutic resetting of genes in the elderly

That kind of response is rare in arthritis treatments

Buying multiple 100mg vials makes sense if you plan extended research, expect to run multiple cycles annually, or have reliable freezer storage for long-term powder preservation