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But for a condition as widespread and devastating as addiction, Yammine is eager to help put an additional tool in the treatment toolbox

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This is a potentially lethal complication of metformin therapy that typically occurs when renal dysfunction results in very high blood metformin levels, which inhibit mitochondrial function resulting in the overproduction of lactate (53)

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1 Not well-known until recently, this incretin effect is severely reduced in patients with type 2 diabetes (T2DM) and has been therapeutically exploited to develop an entirely new class of antidiabetic drugs

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Reportedly, no foul play was involved

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However, the reverse reaction of Michael addition is underutilized

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