Overall, the affinitypotency profile of tirzepatide was 360-fold weaker relative to mGIP at the mGIPR, with similar or slightly reduced potency compared to GLP-1 at the mGLP-1R (Extended Data Table 1)
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Levels of reactive oxygen species (ROS) are generally higher in proliferating tumour cells than in normal cells, and this may explain why ROS is a key component in the efficacy of chemotherapeutic drugs (Crohns et al
Kremser M (1989) [Food allergies -- oropharyngeal reactions.] Wien Med Wochenschr, 139(6/7): 135-139
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