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Glucagon concentration was higher during administration of exendin-(9-39) versus the vehicle condition in this study (42)

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"The patients we see who are taking medicines, whether it's Wegovy or (Lilly's) Zepbound, we're not telling them to switch to oral Wegovy if they're doing well," said Dr

A couple of patients mention that swelling in their ankles and feet subsided, allowing them to stand or walk for extended periods

Monitor baseline GH, IGF-1, and sex hormones before and during treatment

The work also suggests that the GLP-1R uses the ER as a platform to reach and signal into many different cellular organelles, not just mitochondria