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While the clinical evaluation of GLP-1MK-801 for weight loss awaits, efforts to broaden the scope of developing peptide-mediated targeting of ion channels are encouraged and should not be restricted to metabolic diseases

Tirzepatide, a dual GIP/GLP-1 receptor agonist, represents the newest class of weight loss medications with remarkable clinical trial results from the SURMOUNT studies (Jastreboff et al., NEJM, 2022)

doi: 10.1016/j.neuropharm.2014.10.007 73 Aviles-OlmosIDicksonJKefalopoulouZDjamshidianAEllPSoderlundTet al

Continuous positive airway pressure with or without liraglutide in obstructive sleep apnoea and type 2 diabetes (ROMANCE)

doi: 10.1016/j.cmet.2013.03.002 149 KlugeMAFettermanJLVitaJA

For this, we suggest enhancing your Metformin remedy with vitamin B12 supplementation