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17 In addition to these findings, the SUSTAIN-6 trial also showed that semaglutide can offer a significant reduction in the risk of new or worsening nephropathy including persistent macroalbuminuria, increase in serum creatinine or the need of renal replacement therapy

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The author of this study hypothesized that the TGF- 1 mediated reduction in GSH synthesis is associated with the decrease in both -GCS protein and the levels of mRNA expression that codes for -GCShs, both of which are essential for maintaining the adequate level of endogenous GSH [81]