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The comprehensive study conducted by Dao-Gen Yin, Liang-Liang Ding, Hai-Rong Zhou, Mei Qiu, and Xue-Yan Duan involved a meta-analysis of 21 trials with 12,260 semaglutide users and 14,176 comparators

2013 Oct;32(5):704-12

By activating GLP-1 receptors in the hypothalamus and other brain regions, semaglutide reduces hunger signals and increases feelings of satiety, leading to lower calorie consumption without restriction-based willpower

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