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Both pathways have independent effects on heart health: GLP-1 reduces inflammation and improves vascular function, while GIP signaling helps regulate blood pressure and endothelial (blood vessel) health

We propose that liver-targeted TR agonists that are capable of uncoupling beneficial effects from deleterious effects could be tested in future clinical studies for the treatment of type 2 diabetes

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Cohort = dose arm within a single trial

The body has enzymes to break down the histamines

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