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Notably, the ephrin pathway, which regulates cell signaling, cellular morphology, stem cell niche maintenance, axon guidance, and energy metabolism was found to be upregulated in ME/CFS patients

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Many mechanisms of plateletleukocyte interactions have been defined, but the initial interaction appears to be mediated primarily by the interaction between P-selectin (CD62P) expressed on the surface of activated platelets and PSGL-1 on the surface of neutrophils and monocytes