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It is released from the extracellular matrix during tissue injury specifically cleaved from SPARC (Secreted Protein Acidic and Rich in Cysteine) and the alpha 2(I) chain of type I collagen.[2] Age-related decline: Plasma concentration declines from approximately 200 ng/mL (10 M) at age 20 to roughly 80 ng/mL by age 60

For six out of the seven patients, sleep returned to normal for three to seven months after treatment

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What makes DSIP particularly interesting is that the human body produces it naturally

Dibaj SS Vailati Negrao M, Zhang J, Lee JJ, Heymach JV, Roarty EB, Rinsurongkawong W, Lewis J, Sepesi B, Simon G, Papadimitrakopiulou V, Reuben A, Futreal A, Glissin BS, Gibbons DL, Blumenschein G, Wistuba II, Roth JA, Swisher SG