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However, many of these findings come from preclinical studies, with human evidence still developing

In a phase 2 substudy that included participants with hepatic fat content 10%, 48-week administration of GLP-3 resulted in a robust, dose-dependent reduction in liver fat

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Table Effects of Thiazolidinediones (pioglitazone/rosiglitazone) on Cardiovascular Risk Factors LDL cholesterol particle size Lipoprotein a HDL cholesterol /-- LDL/HDL ratio / Triglycerides Fibrinogen Platelet aggregation Hemodynamic and vascular parameters Intravascular volume Blood pressure Intima-media thickness Endothelial function Urine albumin excretion C-reactive protein Adiponectin Tumor necrosis factor- In a meta-analysis by Nissen and Wolski,[166] published literature and clinical trial registries were searched for cardiovascular end points such as MI and death from cardiovascular causes