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Leon Barnes, MD , Professor, Department of Pathology, University of Pittsburgh Medical Center Editor(s): Peter Fritsch, MD , Chair, Professor, Department of Dermatology, University of Innsbruck, Austria Michael J Wells, MD , Staff Physician, Department of Dermatology, Texas Tech University Health Sciences Center Drore Eisen, MD, DDS , Consulting Staff, Department of Dermatology, Dermatology Research Associates of Cincinnati Joel M Gelfand, MD, MSCE , Assistant Professor, Department of Dermatology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Hospital William D James, MD , Program Director, Vice-Chair, Albert M Kligman Professor, Department of Dermatology, University of Pennsylvania School of Medicine 2010 Update on new melanoma vaccine trials BACKGROUND: Melanoma is the most serious type of skin cancer