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These three approaches will continue to be assessed in the context of the potent and stable peptide candidates with lower molecular weights that are emerging from medicinal chemistry than have been available before

However, the CagriSema combination showed a higher odds ratio for diarrhea at 6.60 compared to semaglutide alone at 2.37

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Glutathione seems to be well tolerated

Acknowledgements The authors thank the members of the Levy and Thaiss labs for valuable discussions and input