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Mechanism of Action: Selective muscarinic agonist, resistant to hydrolysis by different cholinesterase isoenzymes The same backbone structure as acetylcholine, but with a methyl side group (Figure 1), which is responsible for its selectivity for muscarinic vs nicotinic receptors (Vardanyan & Hruby, 2006)

Nature 503 , 111114 (2013)

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49 mtDNA point mutations and deletions increase exponentially with age, disrupt the assembly of the oxidative phosphorylation complex, reduce adenosine triphosphate (ATP) and increase electron leakage, and form a vicious cycle of ROS-damage-ROS

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