Research confirms no noticeable cell loss in cultures of non-senescent chondrocytes, validating selective targeting capabilities
Ouabain, a natural compound belonging to the cardiac glycosides family, reduces cell survival through apoptotic pathway in human senescent cells induced by genotoxic stress (Etoposide, Doxorubicin and Palbociclib), OIS, or replicative exhaustion
Rafii MS, Tuszynski MH, Thomas RG, Barba D, Brewer JB, et al
The peptide demonstrates effectiveness across an unusually wide dose range in animal studies, with doses from 10 ng/kg to 10 mcg/kg showing comparable efficacy
Improved hepatic insulin sensitivity normalises sex hormone binding globulin (SHBG) production, which in turn lowers free androgens
Sharon, Y., Raz, Y., Cohen, N., Ben-Shmuel, A., Schwartz, H., Geiger, T., et al