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However, no human pharmacokinetic data exists to validate this

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"Initially, it looked to me like homocysteine might be an important storage/transfer molecule and the factors that cause its elevation are the actual problem, not the homocysteine itself." I am currently looking at supplementing with methylfolate (a friendlier version of folic acid) and vitamin B12

Endocrine Society Clinical Practice Guidelines Adult Growth Hormone Deficiency

Splitting ALA into smaller doses may help reduce gastrointestinal side effects, especially at higher intakes.43 Taking ALA with food can also improve tolerability though some studies suggest it may slightly reduce absorption.13 44 That tradeoff may be worth it for users sensitive to GI effects, particularly when taking ALA long-term