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Targeted evaluation is most appropriate when elevation is unexplained, persistent, or paired with red-flag features, with functional markers added when deficiency remains plausible despite a high total

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Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: Results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1)

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