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While vitamin B12 deficiency is rare and most people get enough B12 from their diets, some people may be at greater risk of low B12 levels, including vegetarians and vegans, older adults and people with digestive system conditions, such as Crohn's disease and celiac disease

But its important to keep expectations realistic: this kind of research is mechanistic and early-stage

Yes, long-term use is safe according to multi-year clinical trials

Conclusion: Sublingual and oral B12 supplementation appear to be as effective as intramuscular (IM) injections in improving cobalamin status and reducing homocysteine levels

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Another thing that is very common with GSH and the addition of B-Vits and Methyl donors is an imbalance of sulfation products causing a transient (but scary) sulfite reaction after an IV