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Therefore, formaldehyde is likely involved in the pathogenesis of type 2 diabetes and that endogenous formaldehyde has the potential to be a biomarker for monitoring the early stages of diabetes [59]

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Strategies to minimize immunogenicity include careful peptide design to maintain similarity to natural sequences, appropriate formulation development, and monitoring for antibody formation during clinical development and post-market surveillance

454 The ongoing phase IIb VIVIAD trial (NCT04498650) aims to further explore its long-term safety, tolerability, effects on cognition, and impact on AD biomarkers

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