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For the behavioral experiment of SPF-Sham and SPF-FUS, mice were tested OFT at 9 weeks of age, CCK-8 injected food intake at 10 weeks of age, saline-injected 11 weeks of age, and motor function test (wire hanging test, ledge test, and hindlimb clasping test, and rotarod test) at 12 weeks of age

Results showed that in PA-treated HUVECs and HFD-fed ApoE / mice, combination of metformin and liraglutide at lower dose significantly improved endothelial dysfunction compared with the single treatment

PMID 14988435.

However, these advancements are accompanied by growing environmental and public health concerns stemming from the release of active pharmaceutical ingredients (APIs) into ecosystems [39, 136]

Protoporphyrin IX is photosensitive and damages the tissues when exposed to UV light

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