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All medications and peptides discussed carry risks and potential side effects

There is limited clinical trial data on this specific combination, and it carries a more complex side effect profile

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For any approved transdermal medication, patients must always follow the specific instructions in the FDA-approved Medication Guide and prescribing information

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This is why Fishman says those with a history of anxiety and insomnia arent great candidates for a bupropion-naltrexone prescription, and thats also why it carries a warning from the FDA that it may lead to suicidal thoughts and behaviors (though the risk is very small)