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These side effects are usually mild to moderate and may decrease or go away entirely after a few days or weeks of treatment

10.1007/978-1-4614-3704-8_19 467 PermyakovE

Estradiol increases body weight loss and gut-peptide satiation after roux-en-Y gastric bypass in ovariectomized rats

However, there are also cases when additional factors such as lack of sleep, poor diet, and deficiency of other vitamins like iron, folate, and others, contribute to the issue