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When thyroid function dropsas in hypothyroidismmetabolic rate can slow by 2040%, making weight gain easier and weight loss harder despite reduced food intake

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These preclinical insights have been validated in large-scale clinical trials.The FLOW trial (n = 3,533) showed that once-weekly subcutaneous administration of semaglutide (1.0 mg) significantly reduced the risk of a renal composite endpointincluding 50% decline in eGFR, renal failure, or cardiovascular deathby 24% in patients with T2DM and chronic kidney disease (CKD) (HR = 0.76, 95% CI: 0.660.88

The half-life of a drug is the amount of time it takes for the concentration of that drug in your bloodstream to be reduced by exactly one-half (50%)

Comparing BPC-157 to alternatives helps contextualize its value

Kwon, Hye S