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It proposes that stimulation of GLP-1 receptors enhances the activity of dopaminergic neurons in the ventral tegmental area (VTA) through a presynaptic mechanism 42

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Demonstrating that a purified protein stimulates GLP-1 release in isolated L cells is not the same as demonstrating that an oral probiotic capsule, after surviving stomach acid and reaching the colon, will colonize effectively and produce enough P9 to meaningfully increase systemic GLP-1 levels in a human being