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Medication Options and Costs Providers typically start patients off with a lower dose of GLP-1s to minimize side effects, and this titration is reflected in the pricing

10.2337/db13-1440

Glucose control The SURPASS studies enrolled populations that were similar in terms of baseline HbA1c levels, which ranged from 7.9 to 8.5% [2, 3, 59,60,61] and found a statistically significant reduction in HbA1c already at the 5 mg dose, demonstrating a greater efficacy of tirzepatide compared to placebo or active comparator [2, 3, 59,60,61]

Knowing what to expect at each stage helps distinguish between a genuine problem and normal fluctuations in progress

Those who took Tirzepatide lost around 25%

[See Warnings and Precautions (5.6)