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DOI: Published online: July 1, 2025 Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea Corresponding author: Hye Jin Yoo Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, 148 Gurodong-ro, Guro-gu, Seoul 08308, Korea E-mail: [email protected] Copyright 2025 Korean Diabetes Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited

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GLP-1 receptor agonists work through several mechanisms: they enhance insulin secretion when blood glucose levels are elevated, suppress glucagon release (which reduces glucose production by the liver), slow gastric emptying, and promote satiety through effects on appetite centres in the brain