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doi: 10.3748/wjg.v18.i4.302 125 KumagaeYHirahashiMTakizawaKYamamotoHGushimaMEsakiMet al

Those with pre-existing bowel conditions, inadequate fluid intake, sedentary lifestyles, or taking other constipating medications (such as opioids, iron supplements, or certain antidepressants) may be at higher risk

consult a professional if concerns arise

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This includes conditions such as joint pain, sleep apnea, insulin resistance, or early signs of kidney injury

For the higher-dose Wegovy HD (7.2 mg), the STEP UP trial showed an average of 18.7% weight loss at 72 weeks, compared to 3.9% with placebo