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Unlike topical formulations, OM avoids issues like scalp irritation and low compliance due to its once-daily oral administration, making it a convenient alternative for patients who struggle with topical application

However, some clinical evidences have presented conflicting evidence, suggesting that the AEs of GLP-1 RAs may not be as severe or widespread as initially thought

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In both comparisons, the semaglutide group demonstrated a significantly greater weight loss, and semaglutide led to more than double the weight reduction compared to dulaglutide at matched doses