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Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production

Increase by 2.5mg every four weeks as tolerated

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A recent investigation revealed that the expression of VRK2 was upregulated in response to ROS signals, while the link between VRK2 and metabolic rewiring remains obscure [18].In this study, we tried to explore the effects of VRK2 on the rewiring of metabolic networks and identify metabolic vulnerabilities resulting from VRK2-driven metabolic reprogramming