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4.4 Biological heterogeneity and value assessment Even if manufacturing and safety hurdles are overcome, the biological heterogeneity of the tumor microenvironment remains a central challenge for the clinical and economic value of TME-oriented nanoplatforms [67, 115]

PMC 3037011

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However, because excessive copper exposure can be harmful, research protocols monitor total copper levels, especially in systemic studies

Vitamin C is required for optimal catalytic activity and demethylation by JHDM (Tsukada et al., 2006)

Its important to note that while DBT therapy is effective for various conditions, individual responses may vary, and its application may be tailored to specific needs