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Fourth, predictive biomarkers capable of reliably stratifying patients for immunotherapy and targeted treatments remain suboptimal, contributing to treatment variability and overtreatment in many cases (329)
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The results showed that GSTF11 and GSTU20 regulate the accumulation of aliphatic GSLs in both leaves and seeds, which is not directly correlated with the gene expression abundance in the particular tissues (Figure 2B), it is more likely GSTU20 play a primary role in the biosynthesis of aliphatic GSLs no matter the transcript level high or low in seed and leaf
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It also summarizes recent advances in drug discovery, including natural compounds, synthetic activators, and NAD + precursors, and evaluates their translational potential for MASLD therapy
