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In most Western nations, gastrointestinal malabsorption is the most common cause of B12 deficiency [2]

This hypothesis is further strengthened by the fact that a mck1 strain (without CYS4 overexpression) shows slight methionine auxotrophy, which is rescued by the expression of wild-type MCK1 but not by a KD form of MCK1 (p.K68R, Lim et al., 1993

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The tetrameric structure of a glutamate receptor channel